Scientists have actually isolated 20 different types of endorphins. Beta-endorphins, the type originally associated with a “runner’s high,” are the most studied. [3] X Trustworthy Source Harvard Medical School Harvard Medical School’s Educational Site for the Public Go to source

Both hormones and neurotransmitters carry messages to either start or stop something from occurring. The only difference is that neurotransmitters stay in your nervous system while hormones travel through your bloodstream.

Research is still ongoing in this area. While studies show that a runner’s high doesn’t depend on endorphins, there still isn’t conclusive evidence that this feeling of euphoria is caused solely by endocannabinoids. Endocannabinoids get their name from the fact that endocannabinoid molecules are structurally similar to cannabis molecules. Similar to endorphins, endocannabinoids are endogenous (internal, natural) versions of a plant-based drug (cannabis). With both endorphins and endocannabinoids, the endogenous substance was named after the drug because scientists knew about the drug before the hormones were isolated and discovered.

The pain-relieving effects of endorphins are relatively short-lived. However, they also trigger the release of other feel-good chemicals, such as dopamine, that have longer-lasting effects.

For example, if you participate in a relatively high-stress activity, such as sky-diving, you’ll experience a spike in endorphins both before and after the activity. The endorphins counter the stress of your initial anticipation and then relieve the stress afterward.

The effects of dopamine also tend to last longer than the effects of endorphins, which tend to taper off within a few minutes of their initial release. Opioid use triggers an excess release of dopamine, which is part of the reason opioids are so addictive.

Apart from the good feelings and increased pain tolerance laughter brings, it’s also important for social bonding and connection. Brainstorm the different types of things that normally make you laugh. Whenever you’re feeling stressed or worried, think about those things to make yourself laugh so you can get that endorphin rush. [13] X Expert Source Carolyn Rubenstein, PhDLicensed Clinical Psychologist Expert Interview. 9 September 2021.

The helper’s high triggers your brain’s reward system, dosing out other feel-good chemicals that can make you feel euphoric, peaceful, and more socially connected.

While exercise might boost your endorphins, scientists have determined that the so-called “runner’s high” is not, in fact, due to an endorphin rush. That particular feeling is more likely caused by endocannabinoids. [16] X Research source

While listening to music alone probably won’t do the trick if you’re dealing with something really painful, like a toothache, it can help you take your mind off of it—which decreases the intensity of the feeling.

Just a few minutes a day is all it takes to get some benefit from these practices. If you find the idea of yoga or meditation intimidating, start with short breathing exercises every couple of hours throughout the day.

If you really want to go for it, try some dark chocolate flavored with peppers for a full-on endorphin rush.

Some researchers also believe endorphins might play some role in regulating sexual function generally. Scientists also speculate that higher endorphin levels contribute to feelings of attachment and bonding between sexual partners.

Because acupuncture is considered safe, it’s certainly a treatment you could try if you think you might get something out of it. Talk to your doctor and see if they’d recommend it.

Endorphins also aid “coping” behavior in response to a stressful experience. A lack of endorphins leads to an inability to cope, which results in anxiety and panic.

Researchers speculate that lower levels of endorphins in the brain could prevent the brain from making new neural connections that are necessary for brain growth, learning, and the formation of memories.

Opioids are able to act more quickly because they can move directly into a cell—they don’t have to first bind to receptors, the way endorphins do. The speed with which opioids work is one of the things that makes them a highly addictive substance.

For example, someone who is addicted to exercise might continue to work out excessively because they crave the endorphin release that comes when they put stress on their body.

Outside the context of opioid addiction, your body typically won’t produce more endorphins than you need. Excess endorphins can typically be treated with opioid antagonists, such as naltrexone, along with abstaining from opioids completely. [30] X Research source